Relation between Hormone Risk Factors and Breast Cancer



Breast Cancer is one of the most cancers that affect females over the world and the death rate of the disease reaches 18.2% worldwide including both in men and women. According to National Cancer Institute, breast cancer is a “Cancer that forms in tissues of the breast. The most common type of breast cancer is ductal carcinoma, which begins in the lining of the milk ducts.” But, what stands behind this disease and what are its risk factors?

A new study which is conducted by a group of Indian Researchers at the Government Medical College Aurangabad in Maharashtra, India has investigated a number of hormone risk factors that lie behind this disease. The study stated that “Breast cancer is a heterogeneous multifactorial disease caused due to genetic, reproductive, environmental, and dietary and lifestyle related risk factors.”

This new research which is published in a Journal of Research in Endocrinology was led for 4 years and “a total number of 220 histopathologically diagnosed women with carcinoma of breast…were included in the present hospital based case control study.”

The researchers mentioned that Risk factors for breast cancer are categorized in two groups: Non-modifiable and Modifiable risk factors.” The first category includes “old age, height, personal history of benign or other breast disease, positive family history in first degree relatives, genetic mutations in BRCA1 and BRCA2, menstrual history of early menarche and late menopause, exposure to radiation, breast density mammogram and null parity” while the second category is related to “age at first childbirth, nulliparous women, obesity, less duration of breastfeeding and hormone replacement therapy.”

The research also added that in addition to the aforementioned risk factors “early age at menarche, late menopause, nulliparous state, and first childbirth at late age and less duration of breast feeding are reproductive risk factors.” The study stated also that the consumption of oral contraceptive pills and hormone replacement therapy in addition to obesity are among risk factors behind the development of breast cancer.

This infographic summarizes this.

Breast Cancer Infographic



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